Why do diabetic patients have a higher incidence of developing peripheral arterial disease?  
     
  Why do diabetic patients have increased risk of malperfusion and poor healing at surgical sites?
    

The Zayed Laboratory studies the mechanisms that influence arterial collateral formation and peripheral arterial atheroprogression in the setting of diabetes. We are interested in better understanding why diabetic patients have a significantly higher incidence of developing peripheral arterial disease (PAD) and are at increased risk of malperfusion at healing surgical sites. We hypothesize that arterial phospholipid tissue expression and processing play a central role in this process. Our team of scientists explores this using a complement of biochemical assays, in vivo animal models, and biobank of vascular tissue specimens. Our vascular clinical team translates its findings from bench-to-bedside through ongoing clinical research trials. Ultimately, our aim is to develop effective new therapeutic modalities for the treatment of diabetic patients with progressive PAD.